Jesper Z Haeggström Selected Research

Leukotriene C4

1/2016	Phosphorylation of Leukotriene C4 Synthase at Serine 36 Impairs Catalytic Activity.
2/2014	Crystal structures of leukotriene C4 synthase in complex with product analogs: implications for the enzyme mechanism.
1/2014	Structure and inhibition of mouse leukotriene C4 synthase.
12/2010	Arginine 104 is a key catalytic residue in leukotriene C4 synthase.
12/2010	Increased expression of leukotriene C4 synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm.
10/2008	Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy.
7/2008	High-level expression, purification, and crystallization of recombinant rat leukotriene C(4) synthase from the yeast Pichia pastoris.

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Jesper Z Haeggström Research Topics

Disease

29	Inflammation (Inflammations) 01/2023 - 06/2002
21	Asthma (Bronchial Asthma) 01/2023 - 11/2004
13	Neoplasms (Cancer) 10/2023 - 12/2005
9	Atherosclerosis 10/2013 - 07/2004
8	Cardiovascular Diseases (Cardiovascular Disease) 01/2020 - 05/2007
5	Stroke (Strokes) 10/2023 - 05/2007
5	Infections 01/2019 - 06/2002
4	Abdominal Aortic Aneurysm 11/2018 - 12/2010
3	Arthritis (Polyarthritis) 01/2020 - 06/2002
3	Chronic Obstructive Pulmonary Disease (COPD) 10/2017 - 06/2002
3	Myocardial Infarction 01/2012 - 05/2007
3	Hypersensitivity (Allergy) 04/2011 - 06/2002
2	Melanoma (Melanoma, Malignant) 10/2023 - 01/2023
2	Pain (Aches) 01/2020 - 01/2018
2	Thrombosis (Thrombus) 01/2020 - 01/2018
2	Fever (Fevers) 01/2020 - 01/2018
2	Peritonitis 12/2019 - 10/2015
2	Anaphylaxis (Anaphylactic Shock) 11/2016 - 07/2008
2	Insulinoma 02/2016 - 07/2004
2	Multiple Sclerosis 09/2015 - 05/2008
2	Disease Progression 09/2015 - 04/2012
2	Psoriasis (Pustulosis Palmaris et Plantaris) 07/2015 - 05/2008
2	Atherosclerotic Plaque (Atheroma) 10/2013 - 05/2006
2	Pathologic Neovascularization 08/2013 - 07/2009
2	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 05/2008 - 01/2008
2	Arteriosclerosis 01/2008 - 05/2007
2	Shock 08/2002 - 06/2002
1	Neoplasm Metastasis (Metastasis) 10/2023
1	Neuroinflammatory Diseases 10/2023
1	Ischemic Stroke 10/2023
1	Granuloma 12/2021
1	Aspergillosis 01/2019
1	Vascular Diseases (Vascular Disease) 11/2018
1	Allergic Rhinitis 11/2018
1	Obesity 01/2018
1	Aneurysm (Aneurysms) 01/2018
1	Metabolic Diseases (Metabolic Disease) 01/2018
1	Tuberculosis (Tuberculoses) 01/2018
1	Seasonal Allergic Rhinitis (Hay Fever) 01/2018

Drug/Important Bio-Agent (IBA)

22	LeukotrienesIBA 01/2023 - 06/2002
19	LipidsIBA 10/2023 - 06/2002
15	Leukotriene B4IBA 01/2019 - 06/2002
13	EnzymesIBA 01/2023 - 11/2004
8	Arachidonate 5-Lipoxygenase (5 Lipoxygenase)IBA 01/2019 - 11/2004
7	Leukotriene C4IBA 01/2016 - 07/2008
7	Messenger RNA (mRNA)IBA 07/2015 - 05/2006
6	Proteins (Proteins, Gene)FDA Link 12/2022 - 05/2006
5	ProstaglandinsIBA 01/2018 - 05/2006
5	Arachidonic Acid (Vitamin F)IBA 01/2018 - 07/2004
5	Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA 01/2018 - 10/2008
4	EicosanoidsIBA 01/2020 - 10/2008
4	montelukast (Singulair)FDA Link 11/2018 - 11/2004
4	CathelicidinsIBA 01/2018 - 08/2013
4	Dinoprostone (PGE2)FDA Link 01/2018 - 07/2009
4	Leukotriene A4IBA 02/2014 - 07/2008
3	leukotriene A4 hydrolaseIBA 01/2019 - 05/2006
3	Glutathione (Reduced Glutathione)IBA 01/2018 - 07/2008
3	5-Lipoxygenase-Activating ProteinsIBA 12/2010 - 05/2006
2	Oxygen (Dioxygen)IBA 10/2023 - 01/2012
2	CytokinesIBA 10/2023 - 05/2006
2	Glutathione Transferase (Glutathione S-Transferase)IBA 10/2023 - 01/2023
2	Succinic Acid (Succinate)IBA 01/2022 - 01/2020
2	Epoxy Compounds (Epoxides)IBA 12/2019 - 07/2013
2	Chemotactic FactorsIBA 01/2019 - 07/2004
2	cysteinyl-leukotrieneIBA 11/2018 - 01/2012
2	leukotriene D4 receptor (cysteinyl leukotriene receptor)IBA 11/2018 - 01/2018
2	LipoxinsIBA 01/2018 - 12/2015
2	Lipoxygenase (Lipoxygenase-1)IBA 01/2018 - 10/2008
2	Antimicrobial PeptidesIBA 02/2016 - 08/2014
2	ZymosanIBA 10/2015 - 04/2011
2	SphingolipidsIBA 09/2015 - 07/2015
2	CeramidesIBA 07/2015 - 12/2014
2	Fatty Acids (Saturated Fatty Acids)IBA 02/2014 - 01/2014
2	Membrane Proteins (Integral Membrane Proteins)IBA 01/2014 - 07/2008
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 08/2013 - 04/2011
2	Prostaglandins EIBA 07/2009 - 05/2006
1	Glutathione PeroxidaseIBA 10/2023
1	SeleniumIBA 10/2023
1	microsomal glutathione S-transferase-IIBA 10/2023
1	AutacoidsIBA 01/2023
1	eumelaninIBA 01/2023
1	dopachromeIBA 01/2023
1	Adenosine Triphosphate (ATP)IBA 01/2023
1	AntioxidantsIBA 01/2023
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2023
1	Levodopa (L Dopa)FDA LinkGeneric 01/2023
1	Melanins (Melanin)IBA 01/2023
1	Cysteine (L-Cysteine)FDA Link 12/2022
1	Sulfhydryl Compounds (Thiols)IBA 12/2022
1	Inositol (Myoinositol)IBA 01/2022
1	IgE Receptors (Fc epsilon RI)IBA 01/2022
1	resolvin D4IBA 12/2021
1	resolvin D3IBA 12/2021
1	CD59 AntigensIBA 12/2019
1	GliotoxinIBA 01/2019
1	IronIBA 01/2018
1	Hemin (Panhematin)FDA Link 01/2018
1	artemisinin (artemisinine)IBA 01/2018

Therapy/Procedure

4	Therapeutics 11/2018 - 10/2008
1	Immunotherapy 10/2023